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KMID : 0043320040270111127
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1127 ~ p.1131
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Acetylcholinesterase Inhibitors from the Aerial Parts of Corydalis speciosa
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Kim Dae-Keun
Lee Ki-Taek
Kim Sung-Hoon
Park Hee-Wook
Lim Jong-Pil
Shin Tae-Yong
Eom Dong-Ok
Yang Jae-Heon
Eun Jae-Soon
Baek Nam-In
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Abstract
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In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa. Structures of these compounds were elucidated on the basis of spectroscopic techniques. These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 M, respectively.
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KEYWORD
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Corydalis speciosa, Acetylcholinesterase, Isoquinoline alkaloids
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